Interspecies Pharmacokinetic Scaling

by Iftekhar Mahmood, Ph.D.
Pinehouse Publishers
Rockville, MD

(c) 2005 Pinehouse Publishers
396 pages

0-9766438-0-4 (hard cover)

$160 (15% discount if ordered from publisher's website)

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From the Back Cover --

Interspecies Pharmacokinetic Scaling: Allometric Principles and Applications provides a detailed insight into the allometric scaling of pharmacokinetics (PK) of xenobiotics. The book:

Provides readers with a practical view of allometric scaling and its usefulness in drug development

Provides step by step procedures to scale PK parameters from laboratory animals to humans and offers several approaches for the selection of the first-in-human dose based on predicted PK parameters

Discusses how to scale PK parameters from laboratory animals to large animals and how to select animal dose based on predicted PK parameters

Discusses how to predict maximum tolerated dose (MTD) of anticancer drugs from animals to humans and how to select a dose escalation scheme

Refutes many wrong and outdated views in allometric scaling and provides a fresh and practical look into the allometric scaling of pharmacokinetics

This book is an ideal resource for pharmaceutical scientists, pre-clinical and clinical pharmacologists, toxicologists, physiologists, biochemists, biologists, veterinarians, and environmental health scientists in academic and industry. The book is also of immense value to clinical pharmacists and medical center-based clinicians. The book is also helpful to graduate students in schools of pharmacy and health sciences.

About the Author --

Iftekhar Mahmood, PhD, is a senior clinical Pharmacologist at the Center for Drug Evaluation and Research (CDER), FDA. He holds a Bachelor of Pharmacy degree and a Ph.D. degree in Pharmaceutical Sciences with specialization in pharmacokinetics. Dr. Mahmood joined the FDA in December 1993 and for more than eight years served as a clinical pharmacologist dealing with neuropharmacological products. Since last 3 years, Dr. Mahmood is a clinical pharmacologist for therapeutic proteins. His research interests include interspecies scaling, limited sampling and Bayesian approach in pharmacokinetics, population pharmacokinetics and pharmacodynamics, and absorption kinetics. Dr. Mahmood has published more than 50 scientific papers in peer-reviewed scientific journals. Dr. Mahmood is the recipient of several CDER Intramural Research Grants as well as the recipient of several CDER awards.



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